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Experimental molecule shows promise to treat pigment retinitis

Research on experimental compounds to treat this disease achieved positive results in fish testing.

For the development of this research Pau Gorostiza researcher at the Institut de Bioenginyeria de Catalunya (IBEC), who has been working on the development of light-regulated drugs for more than ten years, carried out tests on fish, adding light-sensitive molecules in a fish tank.

To make further progress in the project, IBEC partnered with the Miguel Hernández de Elche University, the University of Alcalá de Henares, the Centre d'Investigació i Desenvolupament of the CSIC and the Institut de la Mucula in Barcelona.

However, they are still far from the clinical application of this procedure as it is necessary to get the right drug, "we are still far from being able to offer treatment to patients, the one we have tried in fish is not yet good enough for clinical use", explains Gorostiza. The drug chosen should be sensitive to the spectrum of colors that humans are able to see.

However, the work plan considers various tests on larger animals such as pigs, and on human donor retinas before starting human trials. They even plan to perform the first drug tests on blind dogs once they are safe.

The tests get to know if the treatment manages to restore visual acuity, i.e. sharpness and distinction of details.

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