{"id":9857,"date":"2020-09-15T09:27:49","date_gmt":"2020-09-15T14:27:49","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9857"},"modified":"2025-10-21T14:29:36","modified_gmt":"2025-10-21T20:29:36","slug":"clase-de-antibioticos-muestra-promesa-para-tratar-cierto-tipo-de-demencia","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/clase-de-antibioticos-muestra-promesa-para-tratar-cierto-tipo-de-demencia\/","title":{"rendered":"Class of antibiotics shows promise to treat certain types of dementia"},"content":{"rendered":"
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Researchers in the UK found that a class of antibiotics called aminoglycosides could function as a treatment for dementia. <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Aminoglycose may work as a new treatment for frontotemporal dementia. The results of the research were published in Human Molecular Genetics<\/em>, thanks to a collaboration between the University of Kentucky, the UK Department of Molecular and Cellular Biochemistry and the Department of Pathology of UCSF (University of California at San Francisco).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Frontotemporal dementia is the second most common type of dementia after Alzheimer's, however, it is the most common type of early onset, as it usually begins between the age of 40 and 65. This disease mainly affects the frontal and temporal lobes of the brain, causing behavioral changes, difficulty communicating and memory impairment.<\/p>

Haining Zhu, from the UK Department of Molecular and Cellular Biochemistry, discovered this finding, noting that after adding aminoglycosides antibiotics to neural cells with this mutation, they began to produce the full-length progranulin protein, which omitted the mutation.<\/p>

\u201cThese patients' brain cells have a mutation that prevents progranulin from being made. The team found that by adding a small antibiotic molecule to the cells, they could 'trick' the cellular machinery into making it,\u201d said Matthew Gentry, a co-author of the study and also a professor at the British institution.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Specifically, researchers found that two aminoglycosides antibiotics gentamicin and G418 were effective in fixing the mutation and producing functional progranulin. By adding molecules from these two antibiotics the cells affected managed to regain their progranulin level by 50 to 60%.<\/p>

\u201cIf we can get the right resources and physician to work with, we could potentially repurpose this drug. This is an early stage of the study, but it provides an important proof of concept that these aminoglycoside antibiotics or their derivatives can be a therapeutic avenue for frontotemporal dementia,\u201d said Zhu.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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SCIENCE DAILY <\/strong><\/p>

https:\/\/www.sciencedaily.com\/releases\/2020\/01\/200110085556.htm<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Investigadores en el Reino Unido encontraron que una clase de antibi\u00f3ticos llamado aminogluc\u00f3sidos podr\u00edan funcionar como tratamiento contra la demencia. Los aminogluc\u00f3sidos podr\u00edan funcionar como un nuevo tratamiento para la demencia frontotemporal. Los resultados de la investigaci\u00f3n fueron publicados en Human Molecular Genetics, gracias a una colaboraci\u00f3n entre la Universidad de Kentucky, el Departamento de Bioqu\u00edmica Molecular y Celular del Reino Unido y el Departamento de Patolog\u00eda de la UCSF (Universidad de California en San Francisco). La demencia frontotemporal es el segundo tipo de demencia m\u00e1s com\u00fan despu\u00e9s de Alzheimer, sin embargo, es el tipo m\u00e1s com\u00fan de inicio temprano, ya que por lo general comienza entre los 40 y 65 a\u00f1os. Esta enfermedad afecta principalmente los l\u00f3bulos frontal y temporal del cerebro, lo que provoca cambios de comportamiento, dificultades para comunicarse y deterioro de la memoria. Haining Zhu, del Departamento de Bioqu\u00edmica Molecular y Celular del Reino Unido, fue quien descubri\u00f3 este hallazgo, al observar que despu\u00e9s de agregar antibi\u00f3ticos aminogluc\u00f3sidos a las c\u00e9lulas neuronales con esta mutaci\u00f3n, estas comenzaban a producir la prote\u00edna progranulina de longitud completa, lo que omit\u00eda la mutaci\u00f3n. “Las c\u00e9lulas cerebrales de estos pacientes tienen una mutaci\u00f3n que evita que se produzca progranulina. El equipo descubri\u00f3 que, al agregar una peque\u00f1a mol\u00e9cula de antibi\u00f3tico a las c\u00e9lulas, pod\u00edan ‘enga\u00f1ar’ a la maquinaria celular para que la produjera”, dijo Matthew Gentry, un co- autor del estudio y tambi\u00e9n profesor de la instituci\u00f3n brit\u00e1nica. En concreto los investigadores encontraron que dos antibi\u00f3ticos aminogluc\u00f3sidos la gentamicina y el G418 fueron eficaces para fijar la mutaci\u00f3n y producir progranulina funcional. Al agregar mol\u00e9culas de estos dos antibi\u00f3ticos las c\u00e9lulas afectaban lograron recuperar su nivel de progranulina de un 50 a 60%. “Si podemos conseguir los recursos y el m\u00e9dico adecuados con los que trabajar, podr\u00edamos reutilizar potencialmente este f\u00e1rmaco. Esta es una etapa inicial del estudio, pero proporciona una prueba importante del concepto de que estos antibi\u00f3ticos aminogluc\u00f3sidos o sus derivados pueden ser una v\u00eda terap\u00e9utica para la demencia frontotemporal “, dijo Zhu. BIBLIOGRAF\u00cdA SCIENCE DAILY https:\/\/www.sciencedaily.com\/releases\/2020\/01\/200110085556.htm<\/p>","protected":false},"author":1,"featured_media":9858,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,154],"tags":[145],"class_list":["post-9857","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-comunidades-conectadas","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9857"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9857\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9858"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}