{"id":9833,"date":"2020-09-11T09:27:33","date_gmt":"2020-09-11T14:27:33","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9833"},"modified":"2025-10-21T14:29:50","modified_gmt":"2025-10-21T20:29:50","slug":"compuestos-que-inhiben-el-crecimiento-de-cristales-permitirian-disenar-mejores-tratamientos-contra-la-malaria","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/compuestos-que-inhiben-el-crecimiento-de-cristales-permitirian-disenar-mejores-tratamientos-contra-la-malaria\/","title":{"rendered":"Compounds that inhibit crystal growth would allow better malaria treatments to be designed"},"content":{"rendered":"
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This advance that has its foundations in crystallization processes seeks to accelerate drug development.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Researchers from the University of Houston and the University of Brussels published in Nature<\/em> the progress they have made in observing at the molecular level the reaction of compounds that inhibit crystal growth in malaria medicines.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u201cYou would expect using two drugs that attacked crystallization in two different ways would be synergistic, or at the very least additive,\u201d explained Jeffrey Rimer, professor of Chemical and Biomolecular Engineering at the University of Houston and co-author of the article. \u201cInstead, we found that they can work against each other.\u201d<\/p>

The results of medicines used through antagonistic cooperation were less effective together than individually, so this research would allow the design of more effective malaria or malaria treatments.<\/p>

However, the real advantage of this scientific breakthrough for drug development is that it involves a new way of selecting molecules which would allow the development of new treatments in less time.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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For testing in this research, they studied the growth of hematic crystals in the presence of four antimalarial drugs: chloroquine, quinine, mefloquine and amodiaquine.<\/p>

\u201cThis mechanism may provide guidance in the search for suitable inhibitor combinations to control crystallization of pathological, biomimetic, and synthetic materials,\u201d the researchers wrote. \u201cIn a broader context, our results highlight modifier interactions mediated by the dynamics and structures on the crystal interface as a prime element of the regulation of the shapes and patterns of crystalline structures in nature and industry.\u201d<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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UNIVERSITY OF HOUSTON <\/strong><\/p>

https:\/\/uh.edu\/news-events\/stories\/january-2020\/01152020-rimer-vekilov-malaria.php<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Este avance que tiene sus bases en los procesos de cristalizaci\u00f3n busca acelerar el desarrollo de f\u00e1rmacos Un grupo de investigadores de la Universidad de Houston y la Universidad de Bruselas, publicaron en la revista Nature los avances que han tenido al observar a nivel molecular, la reacci\u00f3n de compuestos que inhiben el crecimiento de cristales en medicamentos contra la malaria. \u201cEs de esperar que el uso de dos f\u00e1rmacos que atacan la cristalizaci\u00f3n de dos formas diferentes sea sin\u00e9rgico, o al menos aditivo\u201d, explic\u00f3 Jeffrey Rimer, profesor de Ingenier\u00eda Qu\u00edmica y Biomolecular en la Universidad de Houston y coautor del art\u00edculo. \u201cEn cambio, descubrimos que pueden trabajar unos contra otros\u201d. Los resultados de los medicamentos utilizados a trav\u00e9s de cooperaci\u00f3n antag\u00f3nica mostraban menos efectividad en conjunto que individualmente, por lo que esta investigaci\u00f3n permitir\u00eda el dise\u00f1o de tratamientos m\u00e1s efectivos contra la malaria o paludismo. Sin embargo, la verdadera ventaja de este avance cient\u00edfico para el desarrollo de f\u00e1rmacos es que implica una nueva forma de seleccionar mol\u00e9culas lo que permitir\u00eda desarrollar los nuevos tratamientos en menor tiempo. Para la realizaci\u00f3n de las pruebas en esta investigaci\u00f3n, estudiaron el crecimiento de cristales de hem\u00e1tica en presencia de cuatro f\u00e1rmacos antipal\u00fadicos: cloroquina, quinina, mefloquina y amodiaquina. \u201cEste mecanismo puede proporcionar una gu\u00eda en la b\u00fasqueda de combinaciones de inhibidores adecuadas para controlar la cristalizaci\u00f3n de materiales patol\u00f3gicos, biomim\u00e9ticos y sint\u00e9ticos\u201d, escribieron los investigadores. \u201cEn un contexto m\u00e1s amplio, nuestros resultados destacan las interacciones de modificadores mediadas por la din\u00e1mica y las estructuras en la interfaz de cristal como un elemento principal de la regulaci\u00f3n de las formas y patrones de las estructuras cristalinas en la naturaleza y la industria\u201d. BIBLIOGRAF\u00cdA UNIVERSITY OF HOUSTON https:\/\/uh.edu\/news-events\/stories\/january-2020\/01152020-rimer-vekilov-malaria.php<\/p>","protected":false},"author":1,"featured_media":9834,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,156],"tags":[145],"class_list":["post-9833","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-big-data","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9833"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9833\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9834"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}