{"id":9792,"date":"2020-09-10T09:37:41","date_gmt":"2020-09-10T14:37:41","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9792"},"modified":"2025-10-21T14:30:11","modified_gmt":"2025-10-21T20:30:11","slug":"investigadores-disenan-particulas-de-silice-que-ayudarian-a-tratar-la-obesidad-y-diabetes","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/investigadores-disenan-particulas-de-silice-que-ayudarian-a-tratar-la-obesidad-y-diabetes\/","title":{"rendered":"Researchers design silica particles that would help treat obesity and diabetes"},"content":{"rendered":"
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Earlier this year the results of this study applied on mice were published in the journal Nanomedicine.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Through ingestible molecular traps made from mesoporous silica (MPS) particles introduced into the gut, an effect on food efficiency and other metabolic risk factors could be achieved.<\/p>

The results of this study, applied in mice, demonstrated the potential to reduce energy absorption in the body, which could lead to new methods for treating type 2 diabetes and obesity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u201cWe chose an innovative alternative approach. Mesoporous silica particles (MSP) are a type of ingestible synthetic silica particles that can be produced with a large surface area and a range of pore sizes,\u201d explains Tore Bengtsson of the Wenner-Grenn Institute at Stockholm University in Sweden.<\/p>

The hypothesis raised that particles could be used as \"molecular sieves\" in the gut to trap and block digestive enzymes that break down food and thus reduce energy absorption in the body. To perform the corresponding tests, the mice were fed high calorie and fat diets combined with MSP. The results showed that MSPs reduced food efficiency by 33% which meant lower weight gain in rodents and a positive effect on metabolic profile.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\u201cThe data presented in this study suggest that tailored MSPs could be used to treat obesity and diabetes in humans, especially when taking into account their excellent safety profiles. Since we completed this work, clinical trials have been devised and are now underway,\u201d explains Bengtsson.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tBIBLIOGRAPHY<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

SCIENCE DAILY <\/strong><\/p>

https:\/\/www.sciencedaily.com\/releases\/2020\/01\/200114104041.htm<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

A inicios de este a\u00f1o se publicaron los resultados de este estudio realizado en ratones en la revista Nanomedicine. A trav\u00e9s de trampas moleculares ingeribles hechas a partir de part\u00edculas de s\u00edlice mesoporosas (MPS) introducidas en el intestino, se podr\u00eda lograr un efecto sobre la eficiencia alimentaria y otros factores de riesgo metab\u00f3lico. Los resultados de este estudio, aplicado en ratones, demostraron potencial de reducir la absorci\u00f3n de energ\u00eda en el cuerpo, lo que podr\u00eda conducir a nuevos m\u00e9todos para el tratamiento de diabetes tipo 2 y obesidad. \u201cElegimos un enfoque alternativo innovador. Las part\u00edculas de s\u00edlice mesoporosa (MSP) son un tipo de part\u00edculas de s\u00edlice sint\u00e9tica ingeribles que se pueden producir con una gran \u00e1rea de superficie y una variedad de tama\u00f1os de poros\u201d, explica Tore Bengtsson del Instituto Wenner-Grenn de la Universidad de Estocolmo en Suecia. La hip\u00f3tesis plante\u00f3 que las part\u00edculas podr\u00edan usarse como “tamices moleculares” en el intestino y as\u00ed atrapar y bloquear las enzimas digestivas que descomponen los alimentos y as\u00ed reducir la absorci\u00f3n de energ\u00eda en el cuerpo.  Para realizar las pruebas correspondientes, los ratones fueron alimentados con dietas con alto contenido cal\u00f3rico y en grasas combinado con MSP. Los resultados mostraron que las MSP redujeron la eficiencia alimentaria en un 33% lo que signific\u00f3 un menor aumento de peso en los roedores y un efecto positivo en el perfil metab\u00f3lico. \u201cLos datos presentados en este estudio sugieren que los MSP personalizados podr\u00edan usarse para tratar la obesidad y la diabetes en humanos, especialmente si se tienen en cuenta sus excelentes perfiles de seguridad. Desde que completamos este trabajo, se han dise\u00f1ado ensayos cl\u00ednicos y ahora est\u00e1n en marcha\u201d, explica Bengtsson. BIBLIOGRAF\u00cdA SCIENCE DAILY https:\/\/www.sciencedaily.com\/releases\/2020\/01\/200114104041.htm<\/p>","protected":false},"author":1,"featured_media":9793,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,156,3400,1418],"tags":[145],"class_list":["post-9792","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-big-data","category-diagnostico","category-resena-de-publicaciones-cientificas","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9792","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9792"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9792\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9793"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9792"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9792"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9792"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}