{"id":9780,"date":"2020-09-08T09:31:45","date_gmt":"2020-09-08T14:31:45","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9780"},"modified":"2025-10-21T14:30:25","modified_gmt":"2025-10-21T20:30:25","slug":"utilizan-terapia-genica-para-tratar-la-encefalopatia-traumatica-cronica","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/utilizan-terapia-genica-para-tratar-la-encefalopatia-traumatica-cronica\/","title":{"rendered":"Scientists use gene therapy to treat chronic traumatic encephalopathy"},"content":{"rendered":"
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The study was published by Human gene Therapy, a journal reviewed by Mary Ann Liebert<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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The research revealed advances in gene therapy for the treatment of chronic traumatic encephalopathy (CTE), was conducted by researchers from the Department of Genetic Medicine at Weill Cornell Medical College in New York. The study demonstrated efficacy in direct administration of gene therapy in the brain through tests performed on mice.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Currently there are no specific treatments for CTE, a disorder generated by repeated traumas in the central nervous system, recurrent in soldiers and athletes, especially in football players. Inflammation results in the accumulation of hyperphosphoriailated forms of the Tau protein (pTau).<\/p>

The researchers took on the task of developing an adeno-a partnered virus vector, for the administration of the anti-pTau antibody, and the results showed that, with direct administration of this treatment in the hippocampus of mice with brain injury, a significant reduction in pTau levels was achieved in their central nervous system.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u201cCTE is much more prevalent than was initially realized, and there is currently no therapy available,\u201d says Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Medical School, Worcester, MA. \u201cThis new work from the Crystal laboratory is potentially ground-breaking as a means to remove the offending Tau phoshoprotein.\u201d<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tBIBLIOGRAPHY<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

M LIEBERT<\/strong><\/p>

https:\/\/home.liebertpub.com\/news\/using-gene-therapy-to-treat-chronic-traumatic-encephalopathy\/3639<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

El estudio fue publicado por la revista Human Gene Therapy, revista revisada por la editorial Mary Ann Liebert La investigaci\u00f3n revel\u00f3 avances sobre terapia g\u00e9nica para el tratamiento de la encefalopat\u00eda traum\u00e1tica cr\u00f3nica (ETC), fue realizada por investigadores del Departamento de Medicina Gen\u00e9tica del Colegio M\u00e9dico Weill Cornell, en Nueva York.  El estudio demostr\u00f3 eficacia en la administraci\u00f3n directa de la terapia g\u00e9nica en el cerebro a trav\u00e9s de pruebas realizadas a ratones. En la actualidad no existen tratamientos para espec\u00edficos para ETC, un trastorno generado por traumatismos repetidos en el sistema nerviosos central, recurrente en soldados y deportistas, especialmente en jugadores de futbol americano. La inflamaci\u00f3n da como resultado la acumulaci\u00f3n de formas hiperfosforiladas de la prote\u00edna Tau (pTau). Los investigadores se dieron a la tarea de desarrollar un vector de virus adenoasoaciado, para la administraci\u00f3n del anticuerpo anti-pTau, y los resultados mostraron que, con la administraci\u00f3n directa de este tratamiento en el hipocampo de ratones con lesi\u00f3n cerebral, se logr\u00f3 una reducci\u00f3n significativa en los niveles de pTau en su sistema nervioso central. \u201cLa ETC es mucho m\u00e1s frecuente de lo que inicialmente se pens\u00f3, y actualmente no hay ninguna terapia disponible\u201d, subray\u00f3 Terence R. Flotte, editor en jefe de la revista Human Gene Therapy, profesor de educaci\u00f3n m\u00e9dica y decano, rector y vicecanciller ejecutivo de la Facultad de Medicina de la Universidad de Massachusetts, en Worcester (Estados Unidos). \u201cEste nuevo trabajo es potencialmente innovador como un medio para eliminar la fosfoprote\u00edna Tau ofensiva\u201d. BIBLIOGRAF\u00cdA M LIEBERT https:\/\/home.liebertpub.com\/news\/using-gene-therapy-to-treat-chronic-traumatic-encephalopathy\/3639<\/p>","protected":false},"author":1,"featured_media":9781,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,156,3400,1418],"tags":[145],"class_list":["post-9780","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-big-data","category-diagnostico","category-resena-de-publicaciones-cientificas","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9780","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9780"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9780\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9781"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9780"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9780"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9780"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}