{"id":9776,"date":"2020-09-08T09:24:25","date_gmt":"2020-09-08T14:24:25","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9776"},"modified":"2025-10-21T14:30:29","modified_gmt":"2025-10-21T20:30:29","slug":"investigadores-rompen-las-barreras-cerebrales-para-atacar-tumores","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/investigadores-rompen-las-barreras-cerebrales-para-atacar-tumores\/","title":{"rendered":"Researchers break brain \"barriers\" to attack tumors"},"content":{"rendered":"
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The study was funded primarily by Howard Hughes Medical Institute and the National Institutes of Health, looking for new treatments for patients with brain tumors.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Yale researchers found a way to pass on the brain's natural defenses when they become counterproductive. The research was published in the journal Nature.<\/p>

\u201cPeople had thought there was very little the immune system could do to combat brain tumors,\u201d explained Akiko Iwasaki, lead author of the study, who serves as a professor of immunobiology and biology and cell development.<\/p>

Jean-Leon Thomas, professor of neurology at Yale, also co-authored this research, made annotations on vascular endothelial growth factor (VEGF-C), a gene that stimulates vessels lining the inside of the skull and also collects tissue waste, to be removed by the lymphatic system. Thomas' approach suggests whether VEGF-C could increase immune response if lymphatic drainage were increased.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\u201cThe team introduced VEGF C into the cerebrospinal fluid of mice with glioblastoma and observed an increased level of T cell response to tumors in the brain. When combined with immune system checkpoint inhibitors commonly used in immunotherapy, the VEGF-C treatment significantly extended survival of the mice. In other words, the introduction of VEGF-C, in conjunction with cancer immunotherapy drugs, was apparently sufficient to target brain tumors,\u201d asi it reads in the Yale University press release about this breakthrough.<\/p>

The purpose of the research is to make it known that it is possible to bring such treatments to patients with glioblastoma and provide an alternative to chemotherapy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tBIBLIOGRAPHY<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

YALE<\/strong><\/p>

https:\/\/news.yale.edu\/2020\/01\/15\/scientists-breach-brain-barriers-attack-tumors<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

El estudio fue financiado principalmente por el Instituto M\u00e9dico Howard Hughes y los Institutos Nacionales de Salud, en b\u00fasqueda de nuevos tratamientos para pacientes con tumores cerebrales. Investigadores de Yale, encontraron un m\u00e9todo para traspasar las defensas naturales del cerebro cuando llegan a ser contraproducentes.  La investigaci\u00f3n fue publicada en la revista Nature. \u201cLa gente hab\u00eda pensado que era muy poco lo que el sistema inmunitario pod\u00eda hacer para combatir los tumores cerebrales\u201d, explic\u00f3 Akiko Iwasaki, autora principal del estudio, quien se desempe\u00f1a como profesora de inmunobiolog\u00eda y de biolog\u00eda y desarrollo celular. Por su parte, Jean-Leon Thomas, profesor de neurolog\u00eda en Yale, tambi\u00e9n coautor de esta investigaci\u00f3n            realiz\u00f3 anotaciones sobre el Factor de crecimiento endotelial vascular (VEGF-C, por sus siglas en ingl\u00e9s), gen que estimula los vasos que recubren el interior del cr\u00e1neo y adem\u00e1s recolectan los desechos de tejido, para ser eliminados por el sistema linf\u00e1tico. El planteamiento de Thomas sugiere si el VEGF-C podr\u00eda aumentar la respuesta inmune si se aumentara el drenaje linf\u00e1tico. \u201cEl equipo introdujo VEGF C en el l\u00edquido cefalorraqu\u00eddeo de ratones con glioblastoma y observ\u00f3 un mayor nivel de respuesta de las c\u00e9lulas T a los tumores en el cerebro. Cuando se combina con inhibidores de puntos de control del sistema inmunol\u00f3gico com\u00fanmente usados \u200b\u200ben inmunoterapia, el tratamiento con VEGF-C extendi\u00f3 significativamente la supervivencia de los ratones. En otras palabras, la introducci\u00f3n de VEGF-C, junto con f\u00e1rmacos de inmunoterapia contra el c\u00e1ncer, aparentemente fue suficiente para atacar los tumores cerebrales\u201d, explican en el comunicado de prensa de la Universidad de Yale sobre este avance. El prop\u00f3sito de la investigaci\u00f3n es dar a conocer que es posible llevar este tipo de tratamientos a pacientes con glioblastoma y brindar una alternativa a las quimioterapias. BIBLIOGRAF\u00cdA YALE https:\/\/news.yale.edu\/2020\/01\/15\/scientists-breach-brain-barriers-attack-tumors<\/p>","protected":false},"author":1,"featured_media":9777,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,156,3400,1418],"tags":[145],"class_list":["post-9776","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-big-data","category-diagnostico","category-resena-de-publicaciones-cientificas","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9776"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9776\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9777"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}