{"id":9454,"date":"2020-09-04T09:28:02","date_gmt":"2020-09-04T14:28:02","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9454"},"modified":"2025-10-21T14:30:42","modified_gmt":"2025-10-21T20:30:42","slug":"cientificos-disenan-mosquitos-para-repeler-el-virus-del-dengue","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/cientificos-disenan-mosquitos-para-repeler-el-virus-del-dengue\/","title":{"rendered":"Scientists engineered mosquitoes to repel dengue virus"},"content":{"rendered":"
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Researchers first developed synthetic mosquitoes that seek to neutralize the spread of arboviruses.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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The results of biologist-led research from the University of California at San Diego, were published in the journal PLOS Pathogens. <\/em>Dengue virus (DENV) is endemic to tropical regions around the world, so this multidisciplinary group of scientists devised an effective strategy for mosquito control that spreads the virus.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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In the article they described the development of Aedes aegypti<\/em>, the scientific name of synthetically modified mosquitoes to prevent DENV. \u201cThese mosquitoes express a gene encoding an engineered single-chain variable fragment derived from a broadly neutralizing DENV human monoclonal antibody and have significantly reduced viral infection, dissemination, and transmission rates for all four major antigenically distinct DENV serotypes,\u201d as it reads in the article\u2019s summary.<\/p>

In the summary, the author explains the advances in genetic technology and its importance for the control of this virus worldwide. \u201cRecent advances in genetic technologies has allowed for precise modifications of mosquito genome to make them resistant to infections, thus breaking the transmission cycle. Here we generated engineered Ae. aegypti<\/em> mosquitoes efficiently expressing a DENV-targeting single-chain variable fragment (scFv) derived from a previously characterized broadly neutralizing human antibody, which blocked infection and transmission in these mosquitoes\u201d.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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The results shown considerable progress in developing synthetic mosquito-based strategy to reduce other types of arboviruses such as chikungunya and Zika. This initial research provides a test principle for developing more strategies through genetics to reduce the impact of arbovirus around the world.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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PLOS <\/strong><\/p>

https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1008103<\/a><\/p>

\u00a0<\/strong><\/p>

UNIVERSITY OF CALIFORNIA AT SAN DIEGO<\/strong><\/p>

https:\/\/ucsdnews.ucsd.edu\/pressrelease\/mosquitoes-engineered-to-repel-dengue-virus<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Investigadores desarrollaron por primera vez, mosquitos sint\u00e9ticos que buscan neutralizar la propagaci\u00f3n de virus transmitidos por mosquitos. Los resultados de la investigaci\u00f3n dirigida por bi\u00f3logos de la Universidad de California en San Diego, fueron publicados en la revista PLOS Pathogens. El virus del dengue (DENV), es end\u00e9mico de regiones tropicales en todo el mundo, por ello este grupo multidisciplinario de cient\u00edficos ide\u00f3 una estrategia efectiva para el control de mosquitos que propagan este virus. En el art\u00edculo describieron el desarrollo de Aedes aegypti, la denominaci\u00f3n cient\u00edfica de los mosquitos modificados sint\u00e9ticamente para impedir el DENV. \u201cEstos mosquitos expresan un gen que codifica un fragmento variable monocatenario dise\u00f1ado derivado de un anticuerpo monoclonal humano DENV ampliamente neutralizante y tienen tasas de infecci\u00f3n, diseminaci\u00f3n y transmisi\u00f3n virales significativamente reducidas para los cuatro serotipos principales de DENV antig\u00e9nicamente distintos\u201d, se lee en el resumen del art\u00edculo. Dentro del resumen, el autor explica los avances en tecnolog\u00eda gen\u00e9tica y su importancia para el control de este virus a nivel mundial. \u201cLos avances recientes en las tecnolog\u00edas gen\u00e9ticas han permitido modificaciones precisas del genoma del mosquito para hacerlos resistentes a las infecciones, rompiendo as\u00ed el ciclo de transmisi\u00f3n. Aqu\u00ed generamos Ae. aegypti que expresan eficazmente un fragmento variable monocatenario (scFv) dirigido a DENV derivado de un anticuerpo humano ampliamente neutralizante previamente caracterizado, que bloquea la infecci\u00f3n y la transmisi\u00f3n en estos mosquitos\u201d. Los resultados mostrados significan un avance considerable para desarrollar estrategia con base en mosquitos sint\u00e9ticos, para reducir otros tipos de arbovirus como chikungunya y Zika. Esta investigaci\u00f3n inicial proporciona un principio de prueba para el desarrollo de m\u00e1s estrategias a trav\u00e9s de gen\u00e9tica para reducir el impacto de arbovirus alrededor del mundo. BIBLIOGRAF\u00cdA PLOS https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1008103   UNIVERSITY OF CALIFORNIA AT SAN DIEGO https:\/\/ucsdnews.ucsd.edu\/pressrelease\/mosquitoes-engineered-to-repel-dengue-virus<\/p>","protected":false},"author":1,"featured_media":9455,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,156],"tags":[145],"class_list":["post-9454","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-big-data","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9454"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9454\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9455"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9454"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}