{"id":9409,"date":"2020-09-02T09:41:23","date_gmt":"2020-09-02T14:41:23","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9409"},"modified":"2025-10-21T14:32:40","modified_gmt":"2025-10-21T20:32:40","slug":"metodo-de-alta-tecnologia-para-la-terapia-genica-en-celulas-exactas-del-cuerpo","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/metodo-de-alta-tecnologia-para-la-terapia-genica-en-celulas-exactas-del-cuerpo\/","title":{"rendered":"High-tech method for gene therapy for exact body cells"},"content":{"rendered":"
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Swedish university has been perfecting the method for more than five years, in order to achieve its clinical use in the future.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Neuroscientists at Lund University in Sweden developed a new technology that allows it to design the shell of a virus to achieve gene therapy administration to the type of cell in which the body requires treatment.<\/p>

Gene therapy is used to treat complex diseases such as spinal muscular atrophy or enzyme deficiency. With this method the genetic material is controlled by drugs. To accomplish this task, viruses are grown in laboratories and altered so that they have no adverse effects on humans and thus transport the genetic material to the body cells that require it and replace the damaged genome.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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The process developed at this Swedish university combines computer simulations and modeling, as well as sequencing techniques and genetic technology \u201cThanks to this technology, we can study millions of new virus variants in cell culture and animal models simultaneously. From this, we can subsequently create a computer simulation that constructs the most suitable virus shell for the chosen application\u2013 in this case, the dopamine-producing nerve cells for the treatment of Parkinson's disease\u201d, explains Tomas Bjoklund professor of neuroscience and leader of this project at Lund University for five years.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\u201cYou can view this as dramatically speeding up evolution from millions of years to weeks. The reason we can do this is that we study each \u201cgeneration\u201d of the virus in parallel with all the others in the same nerve cells. Unlike evolution, where only the best suited live on to the next generation, we can also learn what makes the virus work less well through this process. This is crucial when building computer models that interpret all the information\u201d.<\/p>

Thanks to this method researchers have reduced the use of laboratory animals, and conduct more complex studies using variants of the same drug in the same individual. \u201cWe believe that the new synthetic virus we succeeded in creating would be very well suited for gene therapy for Parkinson's disease, for example, and we have high hopes that these virus vectors will be able to be put into clinical use\u201d, Bjoklund concluded.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tBIBLIOGRAPHY<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

LUND UNIVERSITY <\/strong><\/p>

http:\/\/www.lunduniversity.lu.se\/article\/high-tech-method-uniquely-targeted-gene-therapy-developed<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Universidad sueca lleva m\u00e1s de cinco a\u00f1os perfeccionando el m\u00e9todo para lograr su uso cl\u00ednico en el futuro. Neurocient\u00edficos de la universidad de Lund en Suecia, desarrollaron una nueva tecnolog\u00eda que permite dise\u00f1ar el “caparaz\u00f3n” de un virus para lograr la administraci\u00f3n de terapia g\u00e9nica al tipo de c\u00e9lula en la que el cuerpo requiere tratamiento. La terapia g\u00e9nica es utilizada para el tratamiento de enfermedades complejas tales como la atrofia muscular espinal o deficiencia de enzimas. Con este m\u00e9todo el material gen\u00e9tico es controlado mediante f\u00e1rmacos. Para realizar esta tarea, los virus se cultivan en laboratorios y se alteran para que no tengan efectos adversos en seres humanos y de esta forma transporten el material gen\u00e9tico a las c\u00e9lulas del cuerpo que lo requieran y remplazar el genoma da\u00f1ado. El proceso desarrollado en esta universidad sueca combina simulaciones de computadora y modelado, adem\u00e1s de t\u00e9cnicas de secuenciaci\u00f3n y tecnolog\u00eda gen\u00e9tica. \u201cGracias a esta tecnolog\u00eda, podemos estudiar millones de nuevas variantes de virus en cultivos celulares y modelos animales simult\u00e1neamente. A partir de esto, podemos crear posteriormente una simulaci\u00f3n por computadora que construya la capa de virus m\u00e1s adecuada para la aplicaci\u00f3n elegida, en este caso, las c\u00e9lulas nerviosas productoras de dopamina para el tratamiento de la enfermedad de Parkinson”, explica Tomas Bjoklund profesor de neurociencia y l\u00edder de este proyecto en la Universidad de Lund desde hace cinco a\u00f1os. \u201cPuede ver esto como una aceleraci\u00f3n dram\u00e1tica de la evoluci\u00f3n de millones de a\u00f1os a semanas.\u00a0La raz\u00f3n por la que podemos hacer esto es que estudiamos cada “generaci\u00f3n” del virus en paralelo con todas las dem\u00e1s en las mismas c\u00e9lulas nerviosas.\u00a0A diferencia de la evoluci\u00f3n, donde solo los m\u00e1s adaptados viven hasta la pr\u00f3xima generaci\u00f3n, tambi\u00e9n podemos aprender qu\u00e9 hace que el virus funcione peor a trav\u00e9s de este proceso.\u00a0Esto es fundamental a la hora de construir modelos inform\u00e1ticos que interpreten toda la informaci\u00f3n\u201d. \u201cGracias a este m\u00e9todo los investigadores han reducido el uso de animales de laboratorio, y realizan estudios m\u00e1s complejos utilizando variantes del mismo f\u00e1rmaco en un mismo individuo.\u00a0 \u201cCreemos que el nuevo virus sint\u00e9tico que logramos crear ser\u00eda muy adecuado para la terapia g\u00e9nica para la enfermedad de Parkinson, por ejemplo, y tenemos grandes esperanzas de que estos vectores de virus se puedan utilizar en la cl\u00ednica\u201d, concluy\u00f3 Bjoklund. BIBLIOGRAF\u00cdA LUND UNIVERSITY http:\/\/www.lunduniversity.lu.se\/article\/high-tech-method-uniquely-targeted-gene-therapy-developed<\/p>","protected":false},"author":1,"featured_media":9410,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,156],"tags":[145],"class_list":["post-9409","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-big-data","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9409","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9409"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9409\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9410"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9409"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9409"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9409"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}