{"id":9398,"date":"2020-09-01T09:17:22","date_gmt":"2020-09-01T14:17:22","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9398"},"modified":"2025-10-21T14:32:57","modified_gmt":"2025-10-21T20:32:57","slug":"a-traves-de-tecnicas-computacionales-investigadores-de-la-unam-desarrollaron-modelos-para-medir-el-potencial-de-nuevos-medicamentos","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/a-traves-de-tecnicas-computacionales-investigadores-de-la-unam-desarrollaron-modelos-para-medir-el-potencial-de-nuevos-medicamentos\/","title":{"rendered":"Through computational techniques, UNAM researchers developed models to measure the potential of new drugs"},"content":{"rendered":"
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UNAM Research Group presents advances in computational method that analyzes drugs and their compounds.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Dr. Jos\u00e9 Luis Medina Franco and his computer-aided drug design <\/strong>research group from UNAM's Faculty of Chemistry have begun research on the potential of new drugs. Researchers have generated computational theoretical models and hypotheses about future drugs against diseases such as cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Thanks to computational technology, the time of this type of research can be reduced by five to ten years. Computational techniques used in the pharmaceutical industry and in research centers require a large economic and time investment. \"Computing tools help analyze data, process information, and build models to make it faster,\" explains Dr. Medina Franco.<\/p>

Drug design starts from information analysis and data mining, creating predictive models. And then perform biological tests. \"It predicts which may have biological activity and the selected compounds (two, five, 10) are sent to the biological assessment group.\"<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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In this way, instead of using traditional methods where it was required to randomly test which compound had an impact on a biological compound, computational methods determine which molecules may have biological activity in certain parasites or bacteria.<\/p>

\"Computational tools are used to organize information into databases, map, chemically characterize and describe compounds, as well as prediction models about their potential biological activity,\" Medina Franco said of their models, which have been used in conjunction with UNAM's National Institute of Cancerology to measure clinical uses of cancer drugs.<\/p>

In addition, they are preparing a database on Mexican natural products called BioFACQUIM that contains data on plants, fungi and endemic propolis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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UNAM <\/strong><\/p>

https:\/\/www.dgcs.unam.mx\/boletin\/bdboletin\/2020_014.html<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Grupo de investigaci\u00f3n en la UNAM presenta avances sobre m\u00e9todo computacional que analiza f\u00e1rmacos y sus compuestos. El Dr. Jos\u00e9 Luis Medina Franco y su grupo de investigaci\u00f3n Dise\u00f1o de F\u00e1rmacos Asistido por Computadora de la Facultad de Qu\u00edmica de la UNAM, han comenzado una investigaci\u00f3n sobre el potencial de nuevos f\u00e1rmacos. Los investigadores han generado modelos te\u00f3ricos computacionales e hip\u00f3tesis sobre futuros medicamentos contra enfermedades como el c\u00e1ncer. Gracias a la tecnolog\u00eda computacional, el tiempo de este tipo de investigaci\u00f3n puede reducirse entre cinco y diez a\u00f1os. Las t\u00e9cnicas computacionales utilizadas en la industria farmac\u00e9utica y en centros de investigaci\u00f3n requiere de una gran inversi\u00f3n econ\u00f3mica y de tiempo. \u201cLas herramientas de c\u00f3mputo ayudan a analizar datos, procesar informaci\u00f3n y generar modelos para que sea m\u00e1s r\u00e1pido\u201d, explica el Dr. Medina Franco. El dise\u00f1o de f\u00e1rmacos comienza desde el an\u00e1lisis de la informaci\u00f3n y la miner\u00eda de datos, y de esta forma crear modelos predictivos. Y posteriormente realizar pruebas biol\u00f3gicas. \u201cSe predice cu\u00e1les pueden tener actividad biol\u00f3gica y los compuestos seleccionados (dos, cinco, 10) se mandan al grupo que hace la evaluaci\u00f3n biol\u00f3gica\u201d. De esta forma en lugar de utilizar m\u00e9todos tradicionales donde se requer\u00eda probar de forma aleatoria cu\u00e1l compuesto tuvo impacto en un compuesto biol\u00f3gico, a trav\u00e9s de los m\u00e9todos de c\u00f3mputo se determina qu\u00e9 mol\u00e9culas pueden tener actividad biol\u00f3gica en determinados par\u00e1sitos o bacterias. \u201cLas herramientas computacionales sirven para organizar la informaci\u00f3n en bases de datos, hacer un mapeo, caracterizar y describir qu\u00edmicamente los compuestos, as\u00ed como modelos de predicci\u00f3n sobre su potencial actividad biol\u00f3gica\u201d, mencion\u00f3 Medina Franco sobre sus modelos, que han sido utilizados en conjunto con el Instituto Nacional de Cancerolog\u00eda de la UNAM para medir los usos cl\u00ednicos de medicamentos contra el c\u00e1ncer. Adicionalmente se encuentran preparando una base de datos sobre productos naturales mexicanos llamada BioFACQUIM que contiene datos sobre plantas, fungi y prop\u00f3leos end\u00e9micos. BIBLIOGRAF\u00cdA UNAM https:\/\/www.dgcs.unam.mx\/boletin\/bdboletin\/2020_014.html<\/p>","protected":false},"author":1,"featured_media":9399,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,156],"tags":[145],"class_list":["post-9398","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-big-data","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9398"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9398\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9399"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}