{"id":9394,"date":"2020-08-31T09:30:51","date_gmt":"2020-08-31T14:30:51","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9394"},"modified":"2025-10-21T14:33:00","modified_gmt":"2025-10-21T20:33:00","slug":"nuevo-software-de-codigo-abierto-para-mayor-precision-en-prediccion-de-cancer","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/nuevo-software-de-codigo-abierto-para-mayor-precision-en-prediccion-de-cancer\/","title":{"rendered":"New open source software for greater accuracy in cancer prediction"},"content":{"rendered":"
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Software created by American universities and the UK\u2019s Crick Institue seeks to improve cancer predictions through genetic relationships.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Working in conjunction with several study centers and universities including the Crick Institute, UCLA (University of California, Los Angeles), and its Comprehensive Cancer Center, the Oregon Health & Science University and, the Oxford Big Data Institute and the University of Toronto, new open source software was developed that determines the accuracy of genetic predictions through tumor samples.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Computer tools have now been developed that aim to predict and find genetic characteristics within clinical tumor samples, however, there is no standardization for the evaluation of samples through computational methods.<\/p>

This article, published in Nature Biotechnology, shows the development of software that seeks to establish a benchmark for computer predictions in cancer. The software works through a simulation framework and a scoring system, evaluates how accurately each algorithm works and its effectiveness in measuring genetic diversity such as: the proportion of cancer cells in the tumor sample; the number of genetically different groups of cancer cells in the tumor sample; the proportion of cells within each of these groups; what genetic mutations were in each group; and the genetic relationship between the groups.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Our new framework provides a foundation which, over time as it is run against more tumours, will hopefully become a much-needed, unbiased, gold-standard benchmarking tool for assessing models that aim to characterise a tumour\u2019s genetic diversity,\u201d said lead author Maxime Tarabichi of the Crick Institute's Cancer Genomics Laboratory.<\/p>

Research showed 580 predictions, which added new features to the software to make more effective predictions. \"Computer simulations in cancer genomics are helping us develop more accurate tools, as we understand where these tools perform well, and where they need improvement,\" explained Peter Van Loo of the Cancer Genomics Laboratory.<\/p>

Such advances would benefit patients for specialists to provide them with personalized care and appropriate medications according to their condition.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tBIBLIOGRAPHY<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

THE FRANCIS CRICK INSTITUTE <\/strong><\/p>

https:\/\/www.crick.ac.uk\/news\/2020-01-10_new-open-source-software-judges-accuracy-of-computer-predictions-of-cancer-genetics<\/a><\/p>

\u00a0<\/p>

FCS<\/strong><\/p>

https:\/\/salud.carlosslim.org\/crean-software-de-codigo-abierto-que-juzga-precision-de-predicciones-computacionales-sobre-la-genetica-del-cancer\/<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Software creado por diversas universidades estadounidenses busca mejorar las predicciones de c\u00e1ncer a trav\u00e9s de relaciones gen\u00e9ticas. En un trabajo en conjunto con varios centros de estudio y universidades entre los cuales est\u00e1n el Instituto Crick, la UCLA (Universidad de California en Los \u00c1ngeles), y su Centro Integral de C\u00e1ncer, la universidad de Ciencias y Salud de Oregon, el Big Data Institute de Oxford y la Universidad de Toronto, fue desarrollado un nuevo software de c\u00f3digo abierto que determina la precisi\u00f3n de las predicciones gen\u00e9ticas a trav\u00e9s de muestras de tumores. Actualmente se han desarrollado herramientas inform\u00e1ticas que pretenden predecir y encontrar caracter\u00edsticas gen\u00e9ticas dentro de las muestras de tumores cl\u00ednicos, no obstante, no existe una estandarizaci\u00f3n para la evaluaci\u00f3n de las muestras a trav\u00e9s de m\u00e9todos computacionales. Este art\u00edculo publicado en Nature Biotechnology, muestra el desarrollo de un software que busca establecer un punto de referencia para las predicciones inform\u00e1ticas en c\u00e1ncer. El software funciona a trav\u00e9s de un marco de simulaci\u00f3n y un sistema de puntuaci\u00f3n, eval\u00faa con que precisi\u00f3n funciona cada algoritmo y su efectividad al medir la diversidad gen\u00e9tica como: la proporci\u00f3n de c\u00e9lulas cancerosas en la muestra de tumor; el n\u00famero de grupos gen\u00e9ticamente diferentes de c\u00e9lulas cancerosas en la muestra de tumor; la proporci\u00f3n de c\u00e9lulas dentro de cada uno de estos grupos; qu\u00e9 mutaciones gen\u00e9ticas estaban en cada grupo; y la relaci\u00f3n gen\u00e9tica entre los grupos. \u201cNuestro nuevo marco proporciona una base que, con el tiempo, a medida que se ejecuta contra m\u00e1s tumores, se convertir\u00e1 con suerte en una herramienta de referencia muy necesaria, imparcial y de referencia para evaluar modelos que tienen como objetivo caracterizar la diversidad gen\u00e9tica de un tumor\u201d, mencion\u00f3 el autor principal Maxime Tarabichi, del Laboratorio de Gen\u00f3mica del C\u00e1ncer del Instituto Crick. La investigaci\u00f3n mostr\u00f3 580 predicciones, que agregaron nuevas caracter\u00edsticas al software para realizar predicciones m\u00e1s eficaces. \u201cLas simulaciones por computadora en la gen\u00f3mica del c\u00e1ncer nos est\u00e1n ayudando a desarrollar herramientas m\u00e1s precisas, ya que entendemos d\u00f3nde funcionan bien estas herramientas y d\u00f3nde necesitan mejoras\u201d, explic\u00f3 Peter Van Loo, del Laboratorio de Gen\u00f3mica del C\u00e1ncer. Este tipo de avances beneficiar\u00eda a pacientes para que los especialistas les brinden una atenci\u00f3n personalizada y medicamentos adecuados de acuerdo a su condici\u00f3n. BIBLIOGRAF\u00cdA THE FRANCIS CRICK INSTITUTE https:\/\/www.crick.ac.uk\/news\/2020-01-10_new-open-source-software-judges-accuracy-of-computer-predictions-of-cancer-genetics FCS https:\/\/salud.carlosslim.org\/crean-software-de-codigo-abierto-que-juzga-precision-de-predicciones-computacionales-sobre-la-genetica-del-cancer\/<\/p>","protected":false},"author":1,"featured_media":9395,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,153,1418],"tags":[145],"class_list":["post-9394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-plataformas-digitales","category-resena-de-publicaciones-cientificas","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9394"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9394\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9395"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}