{"id":9361,"date":"2020-08-27T10:22:00","date_gmt":"2020-08-27T15:22:00","guid":{"rendered":"https:\/\/saluddigital.com\/?p=9361"},"modified":"2025-10-21T14:34:08","modified_gmt":"2025-10-21T20:34:08","slug":"investigadores-en-australia-desarrollaron-tecnologia-para-producir-vacunas-mas-seguras-contra-enfermedades-transmitidas-por-mosquitos","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/investigadores-en-australia-desarrollaron-tecnologia-para-producir-vacunas-mas-seguras-contra-enfermedades-transmitidas-por-mosquitos\/","title":{"rendered":"Researchers in Australia developed technology to produce safer vaccines against mosquito-borne diseases"},"content":{"rendered":"
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This scientific and technological breakthrough could help in the future to massively produce safer vaccines.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Researchers from the University of Queensland (UQ) and the QIMR Berghofer Medical Research Institute in Australia have developed technology to produce large-scale \"hybrid\" viruses for use in vaccines, which would also be safer. These viruses would be used for the development of vaccines from mosquito-borne diseases such as Zika or dengue.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Researchers studied different characteristics of the Binjari virus which is inert to humans, in order to produce viruses transmitted by mosquitoes that cannot grow in humans or animals.<\/p>

\u201cWe were originally hoping to gain insights into how mosquito-borne viral diseases evolve \u2013 viruses like Zika, yellow fever and dengue\u201d,said Dr. Jody Hobson-Peters of the UQ School of Chemistry and Molecular Biosciences. \"We also hoped to discover new viruses that could be useful for biotechnology or as biological control agents.\"<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Hobson-Peters also stressed the importance of genetic manipulation on the Binjari virus and its harmless characteristic towards humans: \u201cThe Binjari virus stood out, and while it grows to very high levels in mosquito cells in the lab, it\u2019s completely harmless and cannot infect humans or other vertebrate species\u201d and \u201cIt is incredibly tolerant for genetic manipulation, allowing us to swap important genes from pathogenic viruses like Zika, West Nile and dengue into the Binjari genoma\u201d.<\/p>

This manipulation produces viruses that appeared to be physically identical to disease-causing viruses after being observed through a microscope, however, they could not yet grow in human or animal cells. In this way, the researchers developed through biotechnology the possibility of developing vaccines safely using this method. \u201cThese hybrids cannot infect humans, meaning that manufacture of vaccines and diagnostic reagents don\u2019t require the strict and expensive biosecurity infrastructure ordinarily needed to grow these pathogenic viruses\u201d, they concluded.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\tBIBLIOGRAPHY<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

THE UNIVERSITY OF QUEENSLAND<\/strong><\/p>

https:\/\/www.uq.edu.au\/news\/article\/2019\/12\/safer-viruses-vaccine-research-and-diagnosis<\/a><\/p>

\u00a0<\/p>

FCS HEALTH<\/strong><\/p>

https:\/\/salud.carlosslim.org\/desarrollan-tecnologia-que-permite-producir-virus-mas-seguros-para-su-uso-en-vacunas\/<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Este avance cient\u00edfico y tecnol\u00f3gico podr\u00eda ayudar en un futuro a producir vacunas m\u00e1s seguras en cantidades masivas. Investigadores de la Universidad de Queensland (UQ) y del Instituto de Investigaci\u00f3n M\u00e9dica QIMR Berghofer, en Australia, han desarrollado tecnolog\u00eda para producir virus “h\u00edbridos” a gran escala, para su uso en vacunas, que adem\u00e1s ser\u00edan m\u00e1s seguros. Estos virus ser\u00edan utilizados para el desarrollo de vacunas de enfermedades transmitidas por mosquitos como Zika o dengue. Los investigadores estudiaron diferentes caracter\u00edsticas el virus Binjari que es inerte para los humanos, para as\u00ed producir virus transmitidos por mosquitos que no pueden crecer en humanos o animales. \u201cOriginalmente esper\u00e1bamos obtener informaci\u00f3n sobre c\u00f3mo evolucionan las enfermedades virales transmitidas por mosquitos, partiendo de virus como el Zika, la fiebre amarilla y el dengue\u201d, coment\u00f3 el Dr. Jody Hobson-Peters, de la Facultad de Qu\u00edmica y Biociencias Moleculares de la UQ. \u201cTambi\u00e9n esper\u00e1bamos descubrir nuevos virus que pudieran ser \u00fatiles para la biotecnolog\u00eda o como agentes de control biol\u00f3gico\u201d. Hobson-Peters tambi\u00e9n destac\u00f3 la importancia de la manipulaci\u00f3n gen\u00e9tica sobre el virus Binjari y su caracter\u00edstica inofensiva hacia humanos: \u201cEl virus Binjari se destac\u00f3 y, aunque crece a niveles muy altos en las c\u00e9lulas de los mosquitos en el laboratorio, es completamente inofensivo y no puede infectar a los humanos ni a otras especies de vertebrados\u201d. \u201cEs incre\u00edblemente tolerante con la manipulaci\u00f3n gen\u00e9tica, lo que nos permite intercambiar genes importantes de virus pat\u00f3genos como el Zika, el Nilo Occidental y el dengue en el genoma de Binjari\u201d. Esta manipulaci\u00f3n produce virus que parec\u00edan ser f\u00edsicamente id\u00e9nticos a los virus causantes de las enfermedades tras ser observados a trav\u00e9s de un microscopio, sin embargo, a\u00fan no pod\u00edan crecer en c\u00e9lulas humanas o animales. De esta forma, los investigadores desarrollaron a trav\u00e9s de biotecnolog\u00eda la posibilidad de desarrollar vacunas de forma segura utilizando este m\u00e9todo.  \u201cEstos h\u00edbridos no pueden infectar a los humanos, lo que significa que la fabricaci\u00f3n de vacunas y reactivos de diagn\u00f3stico no requiere la infraestructura de bioseguridad estricta y costosa que normalmente se necesita para hacer crecer estos virus pat\u00f3genos\u201d, concluyeron. BIBLIOGRAF\u00cdA THE UNIVERSITY OF QUEENSLAND https:\/\/www.uq.edu.au\/news\/article\/2019\/12\/safer-viruses-vaccine-research-and-diagnosis SALUD FCS https:\/\/salud.carlosslim.org\/desarrollan-tecnologia-que-permite-producir-virus-mas-seguros-para-su-uso-en-vacunas\/<\/p>","protected":false},"author":1,"featured_media":9362,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[152,156],"tags":[145],"class_list":["post-9361","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-avance-de-la-ciencia","category-big-data","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=9361"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/9361\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/9362"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=9361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=9361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=9361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}