{"id":25136,"date":"2022-05-09T08:48:17","date_gmt":"2022-05-09T13:48:17","guid":{"rendered":"https:\/\/saluddigital.com\/?p=25136"},"modified":"2025-10-20T11:58:43","modified_gmt":"2025-10-20T17:58:43","slug":"retos-y-oportunidades-de-los-ensayos-clinicos-descentralizados","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/big-data\/retos-y-oportunidades-de-los-ensayos-clinicos-descentralizados\/","title":{"rendered":"Challenges and opportunities of decentralized clinical trials"},"content":{"rendered":"
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t

Decentralized clinical trials allow the development of new effective treatments through more inclusive and diverse clinical research.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Traditional clinical trials often include unrepresentative populations since minority groups, whether due to geographical limitations, lack of communication or even discrimination, are often excluded. This is one of the advantages of decentralized trials by having an intersectional and inclusive vision. In this way, barriers can be reduced to create more complete studies, attract more participants and also reduce research costs.<\/p>

The main difference between traditional and decentralized trials is that the former require participants to regularly visit the site where the study is carried out and, on the other hand, decentralized trials combine the use of software, information technology and visits from professionals to the residence of the participants.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Similarly, decentralized clinical trials imply new challenges, such as closing the digital divide, standardizing procedures and the need to create a new infrastructure. In other words, there is great diversity in the challenges related to the adoption of this type of assay, however, it is to overcome even greater challenges in clinical research, such as underrepresentation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

The US Food and Drug Administration (FDA) has explained that decentralized clinical trials "can ease the burden of participating in a clinical trial and potentially improve recruitment and retention of diverse participants."<\/p>

One of the advantages of decentralized trials is digital recruitment, since it can achieve the elimination of certain geographical limitations for study participants and also provides benefits for participants such as managing their time so as not to interfere with their usual activities.<\/p>

\u201cAnother common element of DCT approaches is electronic informed consent (eConsent), a feature that can be supported by a series of video vignettes, which explain the study in an engaging format,\u201d explains an article published in npj Digital Medicine. . In this way, patients interact with electronic consent solutions, without feeling pressured to read and understand long, printed documents used in traditional trials.<\/p>

Learn more about the challenges and opportunities of decentralized clinical trials at the following link: https:\/\/www.nature.com\/articles\/s41746-022-00603-y<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t BIBLIOGRAPHY<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

NATURE<\/strong><\/p>

https:\/\/www.nature.com\/articles\/s41746-022-00603-y<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Los ensayos cl\u00ednicos descentralizados permiten desarrollar nuevos tratamientos efectos a trav\u00e9s de investigaciones cl\u00ednicas m\u00e1s incluyentes y diversas. Los ensayos cl\u00ednicos tradicionales suelen incluir poblaciones poco representativas ya que los grupos minoritarios ya sea por limitaciones geogr\u00e1ficas, falta de comunicaci\u00f3n o incluso discriminaci\u00f3n, suelen ser excluidos. Esta es una de las ventajas que tienen los ensayos descentralizados al contar con una visi\u00f3n interseccional e inclusiva. De esta forma se pueden reducir barreras para crear estudios m\u00e1s completos, atraer a m\u00e1s participantes y adem\u00e1s reducir costos en investigaci\u00f3n. La principal diferencia entre ensayos tradicionales y descentralizados, es que los primeros requieren que los participantes visiten de manera regular el sitio donde se realiza el estudio y, por otra parte, los descentralizados combinan el uso de software, tecnolog\u00edas de la informaci\u00f3n y visitas de los profesionales a la residencia de los participantes. De igual forma los ensayos cl\u00ednicos descentralizados implican nuevos retos, como cerrar la brecha digital, estandarizar procedimientos y la necesidad de crear una nueva infraestructura. Es decir, existe una gran diversidad en los desaf\u00edos relacionados con la adopci\u00f3n de este tipo de ensayos, no obstante, es para vencer desaf\u00edos todav\u00eda m\u00e1s grandes en la investigaci\u00f3n cl\u00ednica, como la subrepresentaci\u00f3n. La Administraci\u00f3n de Alimentos y Medicamentos de Estados Unidos (FDA), ha explicado que los ensayos cl\u00ednicos descentralizados \u201cpueden aliviar la carga de participar en un ensayo cl\u00ednico y potencialmente mejorar el reclutamiento y la retenci\u00f3n de diversos participantes\u201d. Una de las ventajas de los ensayos descentralizados, es el reclutamiento digital, ya que puede lograr la eliminaci\u00f3n de ciertas limitaciones geogr\u00e1ficas para los participantes del estudio y adem\u00e1s brinda beneficios para los participantes como un manejo de sus tiempos para no interferir con sus actividades habituales. \u201cOtro elemento com\u00fan de los enfoques de DCT es el consentimiento informado electr\u00f3nico (eConsent), una caracter\u00edstica que puede estar respaldada por una serie de vi\u00f1etas de video, que explican el estudio en un formato atractivo\u201d, explica un art\u00edculo publicado en npj Digital Medicina. De esta forma los pacientes interact\u00faan con las soluciones de consentimiento electr\u00f3nico, sin sentirse presionados al leer y comprender documentos largos e impresos que se utilizan en ensayos tradicionales. Conoce m\u00e1s sobre los retos y oportunidades de los ensayos cl\u00ednicos descentralizados en el siguiente enlace: https:\/\/www.nature.com\/articles\/s41746-022-00603-y BIBLIOGRAF\u00cdA NATURE https:\/\/www.nature.com\/articles\/s41746-022-00603-y<\/p>","protected":false},"author":1,"featured_media":25138,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[156,160,3396],"tags":[145],"class_list":["post-25136","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-big-data","category-noticias","category-uso-de-plataformas-digitales","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/25136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=25136"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/25136\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/25138"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=25136"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=25136"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=25136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}