{"id":23493,"date":"2022-01-10T08:41:04","date_gmt":"2022-01-10T14:41:04","guid":{"rendered":"https:\/\/saluddigital.com\/?p=23493"},"modified":"2025-10-21T10:31:51","modified_gmt":"2025-10-21T16:31:51","slug":"aprendizaje-automatico-para-la-visualizacion-de-reparacion-de-dano-al-adn-daria-origen-a-nuevos-tratamientos-contra-el-cancer","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/big-data\/aprendizaje-automatico-para-la-visualizacion-de-reparacion-de-dano-al-adn-daria-origen-a-nuevos-tratamientos-contra-el-cancer\/","title":{"rendered":"Machine learning to visualize DNA damage repair could lead to new cancer treatments"},"content":{"rendered":"
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Scientists from the Massachusetts General Hospital and the National Cancer Research Center (CNIO) of Spain, discovered by using machine learning how the genetic damage repair process works, which prevents mutations.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Scientists from the Metabolism and Cell Signaling Group of the CNIO and the Massachusetts General Hospital managed to visualize cellular DNA repair, thanks to machine learning techniques and a high-performance microscope.<\/p>

DNA cell injuries occur up to 10,000 times each day in a person. However, the same cells repair themselves and prevent the appearance of mutations and diseases such as cancer. In this way, the advance achieved by scientists in Boston and Madrid, which were already published in the journal Cell reports<\/em>, could give rise to new treatments and therapies against cancer.<\/p>

When there is DNA damage, your cells activate a mechanism that causes proteins to immediately bind to the damaged parts of the DNA, which are able to repair it. This process is the one that scientists have managed to observe in more detail.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u201cBy knowing how DNA damage occurs and how it is repaired, we will learn more about how cancer develops and how we can fight it. Any new discovery in DNA repair will help to develop better therapies against cancer, while protecting our healthy cells\u201d, explained researcher B\u00e1rbara Mart\u00ednez from the CNIO.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Mart\u00ednez also explained that one of the limitations of monitoring DNA repair kinetics was the inability to process and analyze such amounts of data generated from images taken by microscope.<\/p>

However, thanks to the use of high-performance microscopy and machine learning, it has led researchers to discover nine new proteins that are part of the DNA repair process.<\/p>

\u201cWe saw that many proteins stuck to the damaged DNA and others did the opposite: they moved away from the DNA lesions. The fact that they bind to or remove from damaged DNA, to allow recruitment of repair proteins to the injury, is a common feature of DNA repair proteins. Both phenomena are relevant\u201d, explained Mart\u00ednez.<\/p>

In this sense, the use of this technology offers new opportunities to study this repair process. To read more about this finding, go to the following link: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721016764<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t BIBLIOGRAPHY<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

HEALTH IT ANALYTICS<\/strong><\/p>

https:\/\/healthitanalytics.com\/news\/machine-learninghelps-repair-genetic-damage<\/a><\/p>

EUREKALERT<\/strong><\/p>

https:\/\/www.eurekalert.org\/news-releases\/938977<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Cient\u00edficos del Hospital General de Massachusetts y el Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO) de Espa\u00f1a, descubrieron mediante el uso de aprendizaje autom\u00e1tico c\u00f3mo funciona el proceso de reparaci\u00f3n de da\u00f1o gen\u00e9tico, el cual previene mutaciones. Cient\u00edficos del Grupo de Metabolismo y Se\u00f1alizaci\u00f3n Celular del CNIO y del Hospital General de Massachusetts, lograron visualizar la reparaci\u00f3n celular de ADN, gracias a t\u00e9cnicas de aprendizaje autom\u00e1tico y un microscopio de alto rendimiento. Las lesiones de c\u00e9lulas de ADN ocurren hasta 10 mil veces cada d\u00eda en una persona. Sin embargo, las mismas celular se reparan y evitan la aparici\u00f3n de mutaciones y enfermedades como el c\u00e1ncer. De esta forma, el avance logrado por cient\u00edficos en Boston y Madrid, que ya fueron publicados en la revista Cell Reports, podr\u00edan dar origen a nuevos tratamiento y terapias conta el c\u00e1ncer. Cuando hay da\u00f1o en el ADN, sus c\u00e9lulas activan un mecanismo que hace que las prote\u00ednas se unen de forma inmediata a las partes da\u00f1adas del ADN, las cuales logran repararlo. Este proceso es el que los cient\u00edficos han logrado observar m\u00e1s a detalle. \u201cAl saber c\u00f3mo ocurren las lesiones del ADN y c\u00f3mo se reparan, aprenderemos m\u00e1s sobre c\u00f3mo se desarrolla el c\u00e1ncer y c\u00f3mo podemos combatirlo. Cualquier nuevo descubrimiento en la reparaci\u00f3n del ADN ayudar\u00e1 a desarrollar mejores terapias contra el c\u00e1ncer, al tiempo que protege nuestras c\u00e9lulas sanas\u201d, explic\u00f3 la investigadora B\u00e1rbara Mart\u00ednez del CNIO. Mart\u00ednez tambi\u00e9n explic\u00f3 que uno de los limitantes del seguimiento de la cin\u00e9tica de reparaci\u00f3n de ADN, era la incapacidad de procesar y analizar tales cantidades de datos generadas a partir de im\u00e1genes tomadas por microscopio. Sin embargo, gracias al uso de microscopia de alto rendimiento y aprendizaje autom\u00e1tico, ha llevado a los investigadores a descubrir nueve nuevas prote\u00ednas que forman parte del proceso de reparaci\u00f3n del ADN. \u201cVimos que muchas prote\u00ednas se adhirieron al ADN da\u00f1ado y otras hicieron todo lo contrario: se alejaron de las lesiones del ADN. El hecho de que se unan o se eliminen del ADN da\u00f1ado, para permitir el reclutamiento de prote\u00ednas reparadoras en la lesi\u00f3n, es una caracter\u00edstica com\u00fan de las prote\u00ednas reparadoras del ADN. Ambos fen\u00f3menos son relevantes”, explic\u00f3 Mart\u00ednez. En este sentido, el uso de esta tecnolog\u00eda ofrece nuevas oportunidades para estudiar este proceso de reparaci\u00f3n. Para leer m\u00e1s sobre este hallazgo ingresa en el siguiente enlace: https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721016764 BIBLIOGRAF\u00cdA HEALTH IT ANALYTICS https:\/\/healthitanalytics.com\/news\/machine-learninghelps-repair-genetic-damage EUREKALERT https:\/\/www.eurekalert.org\/news-releases\/938977<\/p>","protected":false},"author":1,"featured_media":23495,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3399,156,3393,160,1418],"tags":[145],"class_list":["post-23493","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ai-analitica","category-big-data","category-inteligencia-artificial-y-ciencia","category-noticias","category-resena-de-publicaciones-cientificas","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/23493","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=23493"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/23493\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/23495"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=23493"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=23493"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=23493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}