{"id":15471,"date":"2021-05-27T09:54:29","date_gmt":"2021-05-27T14:54:29","guid":{"rendered":"https:\/\/saluddigital.com\/?p=15471"},"modified":"2025-10-21T12:39:49","modified_gmt":"2025-10-21T18:39:49","slug":"investigadores-utilizaron-una-red-de-datos-clinicos-para-simular-ensayos-clinicos-de-alzheimer","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/big-data\/investigadores-utilizaron-una-red-de-datos-clinicos-para-simular-ensayos-clinicos-de-alzheimer\/","title":{"rendered":"Researchers used a clinical data network to simulate Alzheimer's clinical trials"},"content":{"rendered":"
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In the research article \u201cExploring the feasibility of using real-world data from a large clinical data research network to simulate clinical trials of Alzheimer\u2019s disease,\u201d the authors explored the feasibility of using real-world data (RWD) for clinical trial simulation.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Clinical trials are a vital part of new pharmaceutical drug development and discovery, assessing the efficacy and safety of new drugs, as well as possible reactions in patients.<\/p>

\u201cWhile the rigorously controlled conditions of clinical trials can reduce bias and improve the internal validity of the study results, they also come with the drawbacks of high financial costs and long execution time,\u201d the study explains.<\/p>

Currently, no effective drugs have been developed for the treatment and prevention of Alzheimer's disease, despite large investments in preclinical studies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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The authors propose the simulation of clinical trials, which would not only benefit pharmaceutical companies, but most importantly, patients. \u201cClinical trial simulation (CTS) is valuable to assess the feasibility, investigate the assumptions, and optimize the study design before conducting the actual trials\u201d.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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The research obtained a massive base of information thanks to data from the OneFlorida Clinical Research Consortium, a clinical data research network funded by the Patient-Centered Outcomes Research Institute (PCORI).<\/p>

The research presented the simulation of a clinical trial \u201cconsidering three different simulation scenarios. In the one-arm simulation scenario, we attempted to simulate an external control arm for the original trial.\u201d<\/p>

Check the full study at the following link: https:\/\/www.nature.com\/articles\/s41746-021-00452-1<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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NATURE<\/strong><\/p>

https:\/\/www.nature.com\/articles\/s41746-021-00452-1<\/a> \u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

En el art\u00edculo de investigaci\u00f3n \u201cExplorar la viabilidad de utilizar datos del mundo real de una gran red de investigaci\u00f3n de datos cl\u00ednicos para simular ensayos cl\u00ednicos de la enfermedad de Alzheimer\u201d, los autores exploraron la viabilidad de utilizar datos del mundo real (RWD) para la simulaci\u00f3n de ensayos cl\u00ednicos. Los ensayos cl\u00ednicos son una parte vital para el desarrollo y descubrimiento de nuevos f\u00e1rmacos, a trav\u00e9s de estos se eval\u00faa la eficacia y la seguridad de los nuevos medicamentos, as\u00ed como posibles reacciones en pacientes. \u201cSi bien las condiciones rigurosamente controladas de los ensayos cl\u00ednicos pueden reducir el sesgo y mejorar la validez interna de los resultados del estudio, tambi\u00e9n tienen los inconvenientes de los altos costos financieros y el largo tiempo de ejecuci\u00f3n\u201d, explica el estudio. Actualmente no se han desarrollado f\u00e1rmacos eficaces para el tratamiento y tampoco para la prevenci\u00f3n de Alzheimer, a pesar de las grandes inversiones para la realizaci\u00f3n de estudios precl\u00ednicos. Los autores proponen la simulaci\u00f3n de estudios cl\u00ednicos, que no solo beneficiar\u00edan a las compa\u00f1\u00edas farmac\u00e9uticas, sino a lo m\u00e1s importante, los pacientes. \u201cLa simulaci\u00f3n de ensayos cl\u00ednicos (CTS) es valiosa para evaluar la viabilidad, investigar los supuestos y optimizar el dise\u00f1o del estudio antes de realizar los ensayos reales\u201d. La investigaci\u00f3n obtuvo una base masiva de informaci\u00f3n gracias a los datos del Consorcio de Investigaci\u00f3n Cl\u00ednica OneFlorida, una red de investigaci\u00f3n de datos cl\u00ednicos financiada por el Instituto de Investigaci\u00f3n de Resultados Centrados en el Paciente (PCORI). El trabajo present\u00f3 la simulaci\u00f3n de un ensayo cl\u00ednico \u201cconsiderando tres escenarios de simulaci\u00f3n diferentes. En el escenario de simulaci\u00f3n de un brazo, intentamos simular un brazo de control externo para la prueba original\u201d. Consulta el estudio completo en el siguiente enlace: https:\/\/www.nature.com\/articles\/s41746-021-00452-1 BIBLIOGRAF\u00cdA NATURE https:\/\/www.nature.com\/articles\/s41746-021-00452-1 \u00a0<\/p>","protected":false},"author":1,"featured_media":15472,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[156,3393],"tags":[145],"class_list":["post-15471","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-big-data","category-inteligencia-artificial-y-ciencia","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/15471","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=15471"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/15471\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/15472"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=15471"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=15471"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=15471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}