{"id":12114,"date":"2021-01-21T09:46:32","date_gmt":"2021-01-21T15:46:32","guid":{"rendered":"https:\/\/saluddigital.com\/?p=12114"},"modified":"2025-10-21T13:07:49","modified_gmt":"2025-10-21T19:07:49","slug":"articulo-publicado-en-cell-muestra-analisis-de-mas-de-20-tipos-de-cancer-traves-de-big-data","status":"publish","type":"post","link":"https:\/\/saluddigital.com\/en\/avance-de-la-ciencia\/articulo-publicado-en-cell-muestra-analisis-de-mas-de-20-tipos-de-cancer-traves-de-big-data\/","title":{"rendered":"Article published in Cell shows analysis of more than 20 types of cancer through big data"},"content":{"rendered":"
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Through big data, the researchers analyzed a database of more than 10,000 tumors of the 20 most frequent types of cancer, to achieve the objective of identifying the regulatory proteins that control the information of genomic alterations.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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A specialized team from Columbia University in New York published the article: \"A modular master regulator landscape controls cancer transcriptional identity,\" in which they were able to analyze genomic characteristics of 10,000 tumors of the 20 most recurrent cancers through data intelligence technology or big data.<\/p>

The objective of the study was to identify the regulatory proteins responsible for channeling the information of the genomic alterations and later transforming them into the transcriptional identity of the cancer. \"Integrative genomic analysis, using a network-based approach, identified 407 master regulator (MR) proteins responsible for canalizing the genetics of individual samples from 20 cohorts in The Cancer Genome Atlas (TCGA) into 112 transcriptionally distinct tumor subtypes,\" they mention in the article's abstract.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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The findings reported in the article show the main characteristics that a specific cancer presents, which benefits the accuracy when making a patient's diagnosis. What the researchers call \"transcriptional identity\" is important when defining the characteristics of the tumor and its severity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u00c1lvaro Ayt\u00e9s, co-author of the study, expressed that the results obtained show the hierarchical control of the properties of each tumor and that the degree of activation of the 24 proteins defines the transcriptional identity, which benefits its therapeutic approach.<\/p>

The information and the mathematical and computational models used for the development of the study have been made available to members of the scientific community through a web platform.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t<\/i><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t BIBLIOGRAPHY<\/a>\n\t\t\t\t\t<\/div>\n\n\t\t\t\t\t

INFOSALUS<\/strong><\/p>

https:\/\/www.infosalus.com\/salud-investigacion\/noticia-identifican-vulnerabilidades-clave-cancer-big-data-20210112102245.html<\/a><\/p>

\u00a0<\/p>

CELL<\/strong><\/p>

https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(20)31617-2<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

A trav\u00e9s de big data, los investigadores analizaron una base de datos de m\u00e1s de 10 mil tumores de los 20 tipos de c\u00e1ncer m\u00e1s frecuentes, para alcanzar el objetivo de identificar las prote\u00ednas reguladoras que controlan la informaci\u00f3n de alteraciones gen\u00f3micas. Un equipo especializado perteneciente a la Universidad de Columbia en Nueva York public\u00f3 el art\u00edculo: “Un panorama modular de reguladores maestros controla la identidad transcripcional del c\u00e1ncer”, en el cual lograron analizar caracter\u00edsticas gen\u00f3micas de 10 mil tumores de los 20 c\u00e1nceres m\u00e1s recurrentes a trav\u00e9s de tecnolog\u00eda de inteligencia de datos o big data. El objetivo del estudio fue identificar las prote\u00ednas reguladoras responsables de canalizar la informaci\u00f3n de las alteraciones gen\u00f3micas y posteriormente transformarlas en la identidad transcripcional del c\u00e1ncer. \u201cEl an\u00e1lisis gen\u00f3mico integrativo, utilizando un enfoque basado en redes, identific\u00f3 407 prote\u00ednas reguladoras maestras (MR) responsables de canalizar la gen\u00e9tica de muestras individuales de 20 cohortes en The Cancer Genome Atlas (TCGA) en 112 subtipos de tumores transcripcionalmente distintos\u201d, mencionan dentro del resumen del art\u00edculo. Los hallazgos transmitidos en el art\u00edculo muestran las caracter\u00edsticas principales que presenta un c\u00e1ncer especifico, lo que beneficia la fiabilidad al momento de realizar un pron\u00f3stico del paciente. Lo que los investigadores denominan como la “identidad transcripcional” es importante al momento de definir las caracter\u00edsticas del tumor y la gravedad del mismo. \u00c1lvaro Ayt\u00e9s, coautor del estudio expres\u00f3 que los resultados obtenidos muestran el control jer\u00e1rquico de las propiedades de cada tumor y que el grado de activaci\u00f3n de las 24 prote\u00ednas definen la identidad transcripcional, lo que beneficia su abordaje terap\u00e9utico. La informaci\u00f3n y los modelos matem\u00e1ticos y computacionales utilizados para el desarrollo del estudio, han sido puestos a disposici\u00f3n de miembros de la comunidad cient\u00edfica a trav\u00e9s de una plataforma web. BIBLIOGRAF\u00cdA INFOSALUS https:\/\/www.infosalus.com\/salud-investigacion\/noticia-identifican-vulnerabilidades-clave-cancer-big-data-20210112102245.html CELL https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(20)31617-2<\/p>","protected":false},"author":1,"featured_media":12115,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3399,152,156,1418],"tags":[145],"class_list":["post-12114","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ai-analitica","category-avance-de-la-ciencia","category-big-data","category-resena-de-publicaciones-cientificas","tag-noticias"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/12114","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/comments?post=12114"}],"version-history":[{"count":0,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/posts\/12114\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media\/12115"}],"wp:attachment":[{"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/media?parent=12114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/categories?post=12114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saluddigital.com\/en\/wp-json\/wp\/v2\/tags?post=12114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}